Systemic Immune Inflammation

Copper and manganese may be associated with increased immunoinflammatory markers. These markers are associated with coronary heart disease, chronic kidney disease, and chronic obstructive pulmonary disease (COPD).

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ASSOCIATION BETWEEN MULTIPLE-HEAVY-METAL EXPOSURES AND SYSTEMIC IMMUNE INFLAMMATION IN A MIDDLE-AGED AND ELDERLY CHINESE GENERAL POPULATION 

Plasma metals Copper and Manganese were positively correlated with immunoinflammatory markers SII, NLR and PLR. While plasma metal Iron was negatively correlated with immunoinflammatory markers SII, NLR, and PLR. 
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Zhao, Linhai et al. “Correction: Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population.” BMC public health vol. 24,1 1745. 30 Jun. 2024, doi:10.1186/s12889-024-19124-2