Obesity

PFAS and heavy metal mixtures are associated with obesity.

ASSOCIATIONS OF CUMULATIVE EXPOSURE TO HEAVY METAL MIXTURES WITH OBESITY AND ITS COMORBIDITIES AMONG U.S. ADULTS IN NHANES 2003-2014
Our study suggests that cumulative exposure to heavy metals as mixtures is associated with obesity and its related chronic conditions such as hypertension and T2DM. Additional research is needed to confirm these findings in longitudinal settings.
Wang, Xin et al. “Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among U.S. adults in NHANES 2003-2014.” Environment international vol. 121,Pt 1 (2018): 683-694. doi:10.1016/j.envint.2018.09.035

ADIPOTROPIC EFFECTS OF HEAVY METALS AND THEIR POTENTIAL ROLE IN OBESITY
Recent findings demonstrated the association between heavy metal exposure and prevalence of obesity. Exposure to markers of mercury, cadmium, lead, and arsenic as well as metal mixture were found to be correlated with anthropometric and metabolic parameters in obesity and metabolic syndrome.
Tinkov, Alexey A et al. “Adipotropic effects of heavy metals and their potential role in obesity.” Faculty reviews vol. 10 32. 26 Mar. 2021, doi:10.12703/r/10-32

PFAS EXPOSURE AND OVERWEIGHT/OBESITY AMONG CHILDREN IN A NATIONALLY REPRESENTATIVE SAMPLE
Findings indicate an association between elevated PFOA and overweight/obesity among children after multivariable adjustment.
Geiger, Sarah Dee et al. “PFAS exposure and overweight/obesity among children in a nationally representative sample.” Chemosphere vol. 268 (2021): 128852. doi:10.1016/j.chemosphere.2020.128852

EXPOSURE TO PERFLUOROALKYL SUBSTANCES (PFAS) AND DYSLIPIDEMIA, HYPERTENSION AND OBESITY IN ADOLESCENTS. THE FIT FUTURES STUDY
This cross-sectional study showed a possible link between several PFAS and dyslipidemia, hypertension and obesity in Norwegian adolescents.
Averina, Maria et al. “Exposure to perfluoroalkyl substances (PFAS) and dyslipidemia, hypertension and obesity in adolescents. The Fit Futures study.” Environmental research vol. 195 (2021): 110740. doi:10.1016/j.envres.2021.110740