Endocrine Disfunction

The endocrine system releases hormones telling our bodies when do everything. This includes growth, development, metabolism, reproduction, mood, homeostasis, and our sleep-wake cycle. Toxins disrupt the normal release of hormones from our various endocrine glands.

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PERSPECTIVES IN ENDOCRINE TOXICITY OF HEAVY METALS- A REVIEW

Toxic metals can cause structural and functional changes in the adrenal glands. Certain metals can cause injury to the endocrine pancreas. Exposure to them can cause diabetes mellitus and disturb insulin homeostasis. 
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Rana, S V S. “Perspectives in endocrine toxicity of heavy metals--a review.” Biological trace element research vol. 160,1 (2014): 1-14. doi:10.1007/s12011-014-0023-7

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EFFECTS OF ENDOCRINE-DISRUPTING HEAVY METALS ON HUMAN HEALTH

​This review collects current knowledge regarding the endocrine-disrupting roles of heavy metals such as lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), nickel (Ni), copper (Cu), zinc (Zn), and manganese (Mn), summarizes the possible molecular mechanisms of these endocrine-disrupting chemicals (EDCs), and briefly evaluates their endocrine toxicity on animals and humans.
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Liu, Dongling et al. “Effects of Endocrine-Disrupting Heavy Metals on Human Health.” Toxics vol. 11,4 322. 29 Mar. 2023, doi:10.3390/toxics11040322

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ENDOCRINE-DISRUPTING CHEMICALS

Particularly well-known endocrine-disrupting chemicals include dichlorodiphenyltrichloroethane (DDT) and other organochlorine pesticides, antifouling agents such as tributyltin, and polychlorinated biphenyls (PCBs), which were used in the manufacture of electrical equipment but subsequently banned from use in many countries (since the 1970s). Per- and polyfluoroalkyl substances (PFASs), which are found in a variety of industrial products including fire-fighting foam, also have endocrine-disrupting properties, as do polybrominated diphenyl ethers (PBDEs), which are used as flame retardants in furnishings and electronics, alkylphenolic compounds (for example, nonylphenols) used in the manufacture of surfactants, and plasticisers like bisphenols and phthalates, which are used to make plastics more pliable. In addition, various pharmaceuticals are extremely potent endocrine-disrupting chemicals, such as the synthetic androgen trenbolone, a growth-promoting steroid that is commonly administered to beef cattle.
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Bertram, Michael G et al. “Endocrine-disrupting chemicals.” Current biology : CB vol. 32,13 (2022): R727-R730. doi:10.1016/j.cub.2022.05.063