Chronic Fatigue

Chronic fatigue symptoms lessen when you reduce the toxic load on your body. This suggests that fatigue can be caused by heavy metal and toxin exposure.

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IMPROVED CHRONIC FATIGUE SYMPTOMS AFTER REMOVAL OF MERCURY IN PATIENT WITH INCREASED MERCURY CONCENTRATION IN HAIR TOXIC MINERAL ASSAY: A CASE

As the primary target is the nervous system, chronic mercury exposure can cause symptoms such as fatigue, weakness, headache, and poor recall and concentration. 
Our patient's toxic chronic fatigue symptoms improved after he was given mercury removal therapy, indicating that he was correctly diagnosed with chronic exposure to organic mercury.
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Shin, Sae-Ron, and A-Lum Han. “Improved chronic fatigue symptoms after removal of mercury in patient with increased mercury concentration in hair toxic mineral assay: a case.” Korean journal of family medicine vol. 33,5 (2012): 320-5. doi:10.4082/kjfm.2012.33.5.320

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HEALTH COMPLAINTS BEFORE AND AT ONE AND FIVE YEARS AFTER REMOVAL OF DENTAL AMALGAM RESTORATIONS-DATA FROM A PROSPECTIVE COHORT STUDY IN NORWAY

​In this study reduction of the intensity of fatigue symptoms after removal of amalgam restorations was observed, which suggests a possible dose–response relationship. 

Mean difference and 95% confidence interval in intensity of local and general health complaints. A) Baseline – 1-year follow-up (Q1–Q2) and B) Baseline – 5-year follow-up (Q1–Q3) in the Amalgam cohort. Positive value indicates improvement of symptoms after removal of amalgam restorations. The dashed line indicates zero change.

​Sinha, Nivedita et al. “Health complaints before and at one and five years after removal of dental amalgam restorations - data from a prospective cohort study in Norway.” Acta odontologica Scandinavica vol. 83 219-229. 3 May. 2024, doi:10.2340/aos.v83.40260

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METALS AS A COMMON TRIGGER OF INFLAMMATION RESULTING IN NON-SPECIFIC SYMPTOMS: DIAGNOSIS AND TREATMENT

In this study, reduction of inflammation-causing metals resulted in an alleviation of symptoms and long-term health improvement. The decrease of metal-specific lymphocyte responses in vitro after removal of sensitizing metals supports the clinical relevance of these findings. 

In addition to their well-known toxic effects, heavy and transition metals might function as immunologically active haptens as well as possess potent adjuvant inflammatory potential. In susceptible patients, chronic low dose exposure to metals may trigger inflammation and exacerbate already existing diseases. Cytokine release with deregulate the HPA axis and trigger non-specific symptoms, including profound fatigue and joint pain. In patients suffering from CFS, fibromyalgia or ASIA, laboratory markers of metal allergy, such as metal-specific memory lymphocytes, should always be measured. The proposed treatment protocol follows the standard procedure used in allergology and dermatology: namely, avoidance of exposure to sensitizing agent(s).

Lastly, it is of utmost importance to increase awareness among health professionals regarding the risk for systemic side effects caused by metal exposure in immunologically sensitized patients.

Stejskal, Vera. “Metals as a common trigger of inflammation resulting in non-specific symptoms: diagnosis and treatment.” The Israel Medical Association journal : IMAJ vol. 16,12 (2014): 753-8.