Cancer

Higher levels of PFOA, arsenic, boron, lithium, chromium, copper, tin, barium, lead, and more are significantly associated the development of cancers. Selenium is associated with lower cancer rates.

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A METALLOMIC APPROACH TO ASSESS ASSOCIATIONS OF SERUM METAL LEVELS WITH GALLSTONES AND GALLBLADDER CANCER

We found there were several metals associated with either gallstones or gallbladder cancer. Among them, arsenic, boron, lithium, and molybdenum were significantly associated with both gallbladder diseases. 
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Lee, Mei-Hsuan et al. “A Metallomic Approach to Assess Associations of Serum Metal Levels With Gallstones and Gallbladder Cancer.” Hepatology (Baltimore, Md.) vol. 71,3 (2020): 917-928. doi:10.1002/hep.30861

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CADMIUM TOXICITY AND TREATMENT: AN UPDATE

​Cadmium compounds were categorized as carcinogenic in humans by International Agency for Research on Cancer (IARC). It may be considered as lung carcinogen, also inducer of prostatic or renal cancers .The important point is that cadmium can disorder testosterone production and induce testicular interstitial cells hyperplasia. Some reports suggested that cadmium may be involved malignancies of liver, hemotopoitic system, bladder and stomach. Furthermore, cadmium may be a potential risk factor for breast cancer. Another study suggested that cadmium exposure may be involved in pancreas cancer because of inducing increased risk for neoplasia.
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Rafati Rahimzadeh, Mehrdad et al. “Cadmium toxicity and treatment: An update.” Caspian journal of internal medicine vol. 8,3 (2017): 135-145. doi:10.22088/cjim.8.3.135

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THE ROLE OF HEAVY METALS IN THE DEVELOPMENT OF COLORECTAL CANCER

Colorectal cancer was positively correlated with Vanadium, Chromium, Copper, Arsenic, Tin, Barium and Lead, but negatively correlated with Selenium. 
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Li, Yongsheng et al. “The role of heavy metals in the development of colorectal cancer.” BMC cancer vol. 23,1 616. 3 Jul. 2023, doi:10.1186/s12885-023-11120-w

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AN OVERVIEW OF CARCINOGENIC HEAVY METAL: MOLECULAR TOXICITY MECHANISM AND PREVENTION

Direct or indirect exposure of heavy metals induces disruption of intracellular processes via complex pathway. In pathway analysis, we found some genes and processes that are common to the toxic effects of As, Cd, Cr, and Ni. These processes might be candidates for markers of heavy metal-induced carcinogenesis. In particular, oxidative stress-mediated pathways are common to toxicity of As, Cd, Cr, and Ni. We might suggest that antioxidative phytochemicals and chelating agents including phytochelatins will be helpful for prevention of heavy metal-induced cancers.
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Kim, Hyun Soo et al. “An Overview of Carcinogenic Heavy Metal: Molecular Toxicity Mechanism and Prevention.” Journal of cancer prevention vol. 20,4 (2015): 232-40. doi:10.15430/JCP.2015.20.4.232

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SERUM CONCENTRATIONS OF PER-AND POLYFLUOROALKYL SUBSTANCES AND RISK OF RENAL CELL CARCINOMA

Our findings add substantially to the weight of evidence that PFOA is a renal carcinogen and may have important public health implications for the many individuals exposed to this ubiquitous and highly persistent chemical.
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Shearer, Joseph J et al. “Serum Concentrations of Per- and Polyfluoroalkyl Substances and Risk of Renal Cell Carcinoma.” Journal of the National Cancer Institute vol. 113,5 (2021): 580-587. doi:10.1093/jnci/djaa143